Accurate FDA PDUFA decision dates for US-listed biotechs — extracted from primary SEC filings, accuracy-tested, and served to your agent per call over x402.
A PDUFA date is the day the FDA is scheduled to decide on a drug — a binary, market-moving event. Biotech Catalyst Sentinel watches both US 8-K filings and foreign-issuer 6-K filings — the foreign disclosures US-only feeds routinely miss — the moment they're published, uses an LLM to extract the decision date, and keeps only dates whose exact wording is quoted verbatim from the filing. The result is a clean, machine-readable feed of upcoming catalysts — one paid endpoint, plus a free, independently verifiable accuracy proof.
Every record links to the exact SEC filing it came from. No press-release telephone game, no aggregated guesses.
Tracks both US 8-K filers and foreign issuers that disclose PDUFA dates via 6-K — names that US-only catalyst feeds routinely overlook.
A date is published only if its source quote appears word-for-word in the filing text. Anything uncertain is held back for human review, never shipped.
Each catalyst is one entity with an event timeline, so date extensions and outcomes update the record instead of creating duplicates.
JSON only, no account, no signup, no subscription. Discoverable and payable autonomously via the x402 standard.
Being right is the entire product. One wrong date on a binary event and an agent operator silently churns forever — so accuracy is measured, published, and free to check before you ever pay.
Figures from a 2023–2024 historical backtest; the live scorecard updates as new decisions resolve.
Two endpoints. One paid, one free. Base URL https://api.biotechcatalystsentinel.com
# Without payment you get the x402 challenge: curl https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming # → HTTP 402 Payment Required (accepts: Base or Solana USDC, $0.02) # Response after payment (one record shown): { "data": [{ "drug_name": "ONS-5010/LYTENAVA (bevacizumab-vikg)", "company": "Outlook Therapeutics, Inc.", "ticker": "OTLK", "indication": "wet AMD", "pdufa_date": "2026-07-29", "stage": "set", "confidence": "high", "source_url": "https://www.sec.gov/Archives/edgar/..." }], "meta": { "total": 1 } }
Agents can auto-discover pricing and schema at /.well-known/x402.
Built on x402, the open HTTP micropayment standard. Any x402-aware client handles the 402 → pay → retry handshake for you — your agent just makes a GET and gets data back.
# Python — an x402 client signs & settles automatically from x402 import x402ClientSync from x402.http.clients.requests import x402_requests # ...register your Base or Solana signer, then: resp = session.get("https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming") print(resp.json()["data"]) # settled in USDC; ~$0.02
Payer pays only the stablecoin — gas is handled by the facilitator. Works with any x402 client (Python, JS x402-fetch, etc.).